Three projects have been established to
- use a genomic approach to broadly identify the role of uncharacterized genes
- determine the role of envelope integrity with regard to bacterial viability
- use expression analysis to identify genes and sRNAs of unknown function associated with drug, disinfectant, and desiccation tolerance
Project Director: Colin Manoil
Title: Assigning function of unknown genes of Acinetobacter baumannii by use of genetic analysis
Project 1 will identify the gene functions responsible for several such resistance traits, and will identify targets for drugs to enhance the efficacy of established antibiotics in treating A. baumannii infections.
Project Director: Samuel I. Miller
Title: Assigning function of unknown genes of Acinetobacter baumannii by cell envelope analysis
Project 2 will define genes of unknown function (GUF) of the Gram-negative A. baumannii that contribute to the structure and barrier function of the cell envelope.
Project Director: Caroline S. Harwood
Title: Assigning function to Acinetobacter baumannii sRNA analysis
Project 3 will utilize RNA-seq analysis to identify and define the functions of sRNA regulators (sRNAs) whose expression is associated with resistance traits of A. baumannii.