Antibiotic Drug Discovery
PI: Dr. Toni KlineDepartment of Immunology
University of Washington, Seattle, WA
This project combines chemistry and biology to identify new compounds of utility in treating or preventing disease caused by Gram-negative bacteria. The project develops high throughput screens, performs chemical synthesis as part of hit-to-lead chemistry, measures the biological effect of compounds with purified enzymes and in whole bacteria, and studies compound efficacy in small animal models of disease.
Currently three separate programs are active: